Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression

BACKGROUND: Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high specificity and low toxicity have emerged as a powerful technology of targeted protein degradation for biomedical applications. FOXM1, a proliferation-associated transcription factor, is overexpressed in a variety...

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Detalles Bibliográficos
Autores principales: Wang, Kun, Dai, Xiaoyong, Yu, Albert, Feng, Chunyan, Liu, Kewei, Huang, Laiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520815/
https://www.ncbi.nlm.nih.gov/pubmed/36171633
http://dx.doi.org/10.1186/s13046-022-02483-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520815/
https://www.ncbi.nlm.nih.gov/pubmed/36171633
http://dx.doi.org/10.1186/s13046-022-02483-2

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