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Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis

BACKGROUND: There has been extensive scrutiny of cancer driving mutations within the exome (especially amino acid altering mutations) as these are more likely to have a clear impact on protein functions, and thus on cell biology. However, this has come at the neglect of systematic identification of...

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Detalles Bibliográficos
Autores principales: Pudjihartono, Michael, Perry, Jo K., Print, Cris, O’Sullivan, Justin M., Schierding, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520844/
https://www.ncbi.nlm.nih.gov/pubmed/36171609
http://dx.doi.org/10.1186/s13148-022-01342-3