New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC(50) values between 0.80 ± 0.05 µM to 40.20 ± 0.70 µM (α-amylase) and 1....

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Detalles Bibliográficos
Autores principales: Khan, Yousaf, Iqbal, Shahid, Shah, Mazloom, Maalik, Aneela, Hussain, Rafaqat, Khan, Shoaib, Khan, Imran, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem, Alahmdi, Mohammed Issa, Abd-Rabboh, Hisham S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520911/
https://www.ncbi.nlm.nih.gov/pubmed/36186602
http://dx.doi.org/10.3389/fchem.2022.995820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520911/
https://www.ncbi.nlm.nih.gov/pubmed/36186602
http://dx.doi.org/10.3389/fchem.2022.995820

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