Mutation in Transmembrane Domain 8 of Human Urate Transporter 1 Disrupts Uric Acid Recognition and Transport

[Image: see text] Human urate transporter 1 (hURAT1) is the most pivotal therapeutic target for hyperuricemia. Due to a lack of crystal structure information, the atomic structure of URAT1 is not clearly understood. In this study, a multiple sequence alignment was performed, and K393, a positively c...

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Detalles Bibliográficos
Autores principales: Lan, Qunsheng, Zhao, Ze’an, Liao, Hui, Zheng, Fengxin, Chen, Yongjun, Wu, Ting, Tian, Yuanxin, Pang, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521027/
https://www.ncbi.nlm.nih.gov/pubmed/36188325
http://dx.doi.org/10.1021/acsomega.2c04543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521027/
https://www.ncbi.nlm.nih.gov/pubmed/36188325
http://dx.doi.org/10.1021/acsomega.2c04543

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