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TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia

TAL1 is ectopically expressed in about 30% of T-cell acute lymphoblastic leukemia (T-ALL) due to chromosomal rearrangements leading to the STIL-TAL1 fusion genes or due to non-coding mutations leading to a de novo enhancer driving TAL1 expression. Analysis of sequence data from T-ALL cases demonstra...

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Detalles Bibliográficos
Autores principales:	Thielemans, Naomi, Demeyer, Sofie, Mentens, Nicole, Gielen, Olga, Provost, Sarah, Cools, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2022
Materias:	Article - Acute Lymphoblastic Leukemia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521226/ https://www.ncbi.nlm.nih.gov/pubmed/35354248 http://dx.doi.org/10.3324/haematol.2021.279718

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