A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia

Chemotherapy is the primary treatment option for acute myeloid leukemia (AML), but leukemic stem cells (LSC) can survive chemotherapy for disease recurrence and refractory. Here, we found that AML cells obtained from relapsed patients had increased autophagy levels than de novo AML cells. Furthermor...

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Detalles Bibliográficos
Autores principales: Xu, Xi, Wang, Jian, Tong, Tong, Zhang, Wenwen, Wang, Jin, Ma, Weiwei, Wang, Shunqing, Zhou, Dunhua, Wu, Jun, Jiang, Linjia, Zhao, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Myeloid Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521229/
https://www.ncbi.nlm.nih.gov/pubmed/35295079
http://dx.doi.org/10.3324/haematol.2021.280290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521229/
https://www.ncbi.nlm.nih.gov/pubmed/35295079
http://dx.doi.org/10.3324/haematol.2021.280290

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