Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets

Approximately 20% of patients receiving multiple platelet transfusions develop platelet alloantibodies, which can be directed against human leukocyte antigens (HLA) and, to a lesser extent, against human platelet antigens (HPA). These antibodies can lead to the rapid clearance of donor platelets, pr...

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Detalles Bibliográficos
Autores principales: van Osch, Thijs L.J., Oosterhoff, Janita J., Bentlage, Arthur E. H., Nouta, Jan, Koeleman, Carolien A. M., Geerdes, Dionne M., Mok, Juk Yee, Heidt, Sebastiaan, Mulder, Arend, van Esch, Wim J. E., Kapur, Rick, Porcelijn, Leendert, van der Schoot, C. Ellen, de Haas, Masja, Wuhrer, Manfred, Voorberg, Jan, Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Platelet Biology & its Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521249/
https://www.ncbi.nlm.nih.gov/pubmed/35354253
http://dx.doi.org/10.3324/haematol.2021.280493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521249/
https://www.ncbi.nlm.nih.gov/pubmed/35354253
http://dx.doi.org/10.3324/haematol.2021.280493

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