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New insights into CAR T cell-mediated killing of tumor cells

Adoptive transfer of T cells genetically engineered to express chimeric antigen receptors (CAR) has demonstrated striking efficacy for the treatment of several hematological malignancies, including B-cell lymphoma, leukemia, and multiple myeloma. However, CAR T-cell efficacy has been very limited in...

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Detalles Bibliográficos
Autores principales: Espie, David, Donnadieu, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521365/
https://www.ncbi.nlm.nih.gov/pubmed/36189315
http://dx.doi.org/10.3389/fimmu.2022.1016208