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On the incongruence of genotype-phenotype and fitness landscapes

The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities that can transform the effects of mutations. For example, mutations may contribute additively to a phenotype, but their effects on fitness may combine non-additively because selection favors a low or interme...

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Detalles Bibliográficos
Autores principales: Srivastava, Malvika, Payne, Joshua L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521842/
https://www.ncbi.nlm.nih.gov/pubmed/36121840
http://dx.doi.org/10.1371/journal.pcbi.1010524