The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

Candida albicans causes severe invasive candidiasis. C. albicans infection requires the virulence factor candidalysin (CL) which damages target cell membranes. However, the mechanism that CL uses to permeabilize membranes is unclear. We reveal that CL forms membrane pores using a unique mechanism. U...

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Detalles Bibliográficos
Autores principales: Russell, Charles M, Schaefer, Katherine G, Dixson, Andrew, Gray, Amber LH, Pyron, Robert J, Alves, Daiane S, Moore, Nicholas, Conley, Elizabeth A, Schuck, Ryan J, White, Tommi A, Do, Thanh D, King, Gavin M, Barrera, Francisco N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522247/
https://www.ncbi.nlm.nih.gov/pubmed/36173096
http://dx.doi.org/10.7554/eLife.75490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522247/
https://www.ncbi.nlm.nih.gov/pubmed/36173096
http://dx.doi.org/10.7554/eLife.75490

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