A spatially resolved stochastic model reveals the role of supercoiling in transcription regulation

In Escherichia coli, translocation of RNA polymerase (RNAP) during transcription introduces supercoiling to DNA, which influences the initiation and elongation behaviors of RNAP. To quantify the role of supercoiling in transcription regulation, we developed a spatially resolved supercoiling model of...

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Detalles Bibliográficos
Autores principales: Geng, Yuncong, Bohrer, Christopher Herrick, Yehya, Nicolás, Hendrix, Hunter, Shachaf, Lior, Liu, Jian, Xiao, Jie, Roberts, Elijah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522292/
https://www.ncbi.nlm.nih.gov/pubmed/36121892
http://dx.doi.org/10.1371/journal.pcbi.1009788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522292/
https://www.ncbi.nlm.nih.gov/pubmed/36121892
http://dx.doi.org/10.1371/journal.pcbi.1009788

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