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The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restricted
A substantial number of human cancers are telomerase-negative and elongate physiologically damaged telomeres through a break-induced replication (BIR)-based mechanism known as alternative lengthening of telomeres (ALT). We recently demonstrated that inhibiting the transcription of the telomeric long...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522348/ https://www.ncbi.nlm.nih.gov/pubmed/36122232 http://dx.doi.org/10.1073/pnas.2208669119 |