CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer

Androgen receptor (AR) messenger RNA (mRNA) alternative splicing variants (AR-Vs) are implicated in castration-resistant progression of prostate cancer (PCa), although the molecular mechanism underlying the genesis of AR-Vs remains poorly understood. The CDK12 gene is often deleted or mutated in PCa...

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Detalles Bibliográficos
Autores principales: Sun, Rui, Wei, Ting, Ding, Donglin, Zhang, Jianong, Chen, Sujun, He, Housheng Hansen, Wang, Liguo, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522376/
https://www.ncbi.nlm.nih.gov/pubmed/36129942
http://dx.doi.org/10.1073/pnas.2205509119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522376/
https://www.ncbi.nlm.nih.gov/pubmed/36129942
http://dx.doi.org/10.1073/pnas.2205509119

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