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Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis
Atherosclerosis treatments by gene regulation are garnering attention, yet delivery of gene cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly of therapeutic oligonucleotides into a three-dimensional spherical nucleic acid nanostructure improves their systemic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522431/ https://www.ncbi.nlm.nih.gov/pubmed/36122215 http://dx.doi.org/10.1073/pnas.2201443119 |