Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice

RNA splicing and epigenetic gene mutations are the most frequent genetic lesions found in patients with myelodysplastic neoplasm (MDS). About 25% of patients present concomitant mutations in such pathways, suggesting a cooperative role in MDS pathogenesis. Importantly, mutations in the splicing fact...

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Detalles Bibliográficos
Autores principales: Garcia-Ruiz, Cristian, Martínez-Valiente, Cristina, Cordón, Lourdes, Liquori, Alessandro, Fernández-González, Raúl, Pericuesta, Eva, Sandoval, Juan, Cervera, José, Gutiérrez-Adán, Alfonso, Sanjuan-Pla, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522584/
https://www.ncbi.nlm.nih.gov/pubmed/36030305
http://dx.doi.org/10.1038/s41375-022-01674-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522584/
https://www.ncbi.nlm.nih.gov/pubmed/36030305
http://dx.doi.org/10.1038/s41375-022-01674-2

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