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Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice
RNA splicing and epigenetic gene mutations are the most frequent genetic lesions found in patients with myelodysplastic neoplasm (MDS). About 25% of patients present concomitant mutations in such pathways, suggesting a cooperative role in MDS pathogenesis. Importantly, mutations in the splicing fact...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522584/ https://www.ncbi.nlm.nih.gov/pubmed/36030305 http://dx.doi.org/10.1038/s41375-022-01674-2 |