Structure of the type V-C CRISPR-Cas effector enzyme

RNA-guided CRISPR-Cas nucleases are widely used as versatile genome-engineering tools. Recent studies identified functionally divergent type V Cas12 family enzymes. Among them, Cas12c2 binds a CRISPR RNA (crRNA) and a trans-activating crRNA (tracrRNA) and recognizes double-stranded DNA targets with...

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Detalles Bibliográficos
Autores principales: Kurihara, Nina, Nakagawa, Ryoya, Hirano, Hisato, Okazaki, Sae, Tomita, Atsuhiro, Kobayashi, Kan, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Yamashita, Keitaro, Scott, David A., Nishimasu, Hiroshi, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522604/
https://www.ncbi.nlm.nih.gov/pubmed/35366394
http://dx.doi.org/10.1016/j.molcel.2022.03.006