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Structure of the type V-C CRISPR-Cas effector enzyme

RNA-guided CRISPR-Cas nucleases are widely used as versatile genome-engineering tools. Recent studies identified functionally divergent type V Cas12 family enzymes. Among them, Cas12c2 binds a CRISPR RNA (crRNA) and a trans-activating crRNA (tracrRNA) and recognizes double-stranded DNA targets with...

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Detalles Bibliográficos
Autores principales:	Kurihara, Nina, Nakagawa, Ryoya, Hirano, Hisato, Okazaki, Sae, Tomita, Atsuhiro, Kobayashi, Kan, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Yamashita, Keitaro, Scott, David A., Nishimasu, Hiroshi, Nureki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522604/ https://www.ncbi.nlm.nih.gov/pubmed/35366394 http://dx.doi.org/10.1016/j.molcel.2022.03.006

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