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Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis
RB transcriptional corepressor 1 (RB1) is a critical regulatory gene in physiological and pathological processes. Genetic mutation is considered to be the main cause of RB1 inactivation. However, accumulating evidence has shown that not all RB1 dysfunction is triggered by gene mutations, and the add...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522773/ https://www.ncbi.nlm.nih.gov/pubmed/36175480 http://dx.doi.org/10.1038/s42003-022-04007-2 |