MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis

MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched miRNA in the hypothalamus, causes obesity in mice. Targeted deletion of miR-7 in Single-minded homolog 1 (Sim1) neurons, a critica...

Descripción completa

Detalles Bibliográficos
Autores principales: LaPierre, Mary P., Lawler, Katherine, Godbersen, Svenja, Farooqi, I. Sadaf, Stoffel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522793/
https://www.ncbi.nlm.nih.gov/pubmed/36175420
http://dx.doi.org/10.1038/s41467-022-33367-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522793/
https://www.ncbi.nlm.nih.gov/pubmed/36175420
http://dx.doi.org/10.1038/s41467-022-33367-w

Ejemplares similares