Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells

Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner proteins, but the actual biochemical mechanism underlying...

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Detalles Bibliográficos
Autores principales: Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González-Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rérolle, Domitille, Tirard, Marilyn, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., de Thé, Hugues, Lallemand-Breitenbach, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522831/
https://www.ncbi.nlm.nih.gov/pubmed/36175410
http://dx.doi.org/10.1038/s41467-022-33147-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522831/
https://www.ncbi.nlm.nih.gov/pubmed/36175410
http://dx.doi.org/10.1038/s41467-022-33147-6

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