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Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells
Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner proteins, but the actual biochemical mechanism underlying...
Autores principales: | Tessier, Sarah, Ferhi, Omar, Geoffroy, Marie-Claude, González-Prieto, Román, Canat, Antoine, Quentin, Samuel, Pla, Marika, Niwa-Kawakita, Michiko, Bercier, Pierre, Rérolle, Domitille, Tirard, Marilyn, Therizols, Pierre, Fabre, Emmanuelle, Vertegaal, Alfred C. O., de Thé, Hugues, Lallemand-Breitenbach, Valérie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522831/ https://www.ncbi.nlm.nih.gov/pubmed/36175410 http://dx.doi.org/10.1038/s41467-022-33147-6 |
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