Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice

Few human tumours present with a recurrent pathognomonic mutation in a transcription factor. Thymomas are an exception, with the majority of some subtypes exhibiting a distinct somatically acquired missense mutation in the general transcription factor GTF2I. Co-dominant expression of wild-type and m...

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Detalles Bibliográficos
Autores principales: Giorgetti, Orlando B., Nusser, Anja, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522929/
https://www.ncbi.nlm.nih.gov/pubmed/36175547
http://dx.doi.org/10.1038/s42003-022-04002-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522929/
https://www.ncbi.nlm.nih.gov/pubmed/36175547
http://dx.doi.org/10.1038/s42003-022-04002-7

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