Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN

Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently promote tumor cell proliferation, survival, me...

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Autores principales: Shi, Xiyao, Wang, Ying, Zhang, Longhui, Zhao, Wenjie, Dai, Xiangpeng, Yang, Yong-Guang, Zhang, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523081/
https://www.ncbi.nlm.nih.gov/pubmed/36187481
http://dx.doi.org/10.3389/fcell.2022.1021820
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author Shi, Xiyao
Wang, Ying
Zhang, Longhui
Zhao, Wenjie
Dai, Xiangpeng
Yang, Yong-Guang
Zhang, Xiaoling
author_facet Shi, Xiyao
Wang, Ying
Zhang, Longhui
Zhao, Wenjie
Dai, Xiangpeng
Yang, Yong-Guang
Zhang, Xiaoling
author_sort Shi, Xiyao
collection PubMed
description Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently promote tumor cell proliferation, survival, metastasis and immune escape. Therefore, BET family proteins are considered attractive therapeutic targets in various cancers. Currently, blocking of the BET proteins is a widely used therapeutic strategy for MYCN amplified high-risk neuroblastoma. Here, we summarized and reviewed the recent research progresses for the critical function of BET proteins, as an epigenetic reader, on tumorigenesis and the therapeutic potential of the BET/BRD4 inhibitors on MYCN amplified neuroblastoma. We also discussed the combined therapeutic strategies for BET inhibitor-resistant neuroblastoma.
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spelling pubmed-95230812022-10-01 Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN Shi, Xiyao Wang, Ying Zhang, Longhui Zhao, Wenjie Dai, Xiangpeng Yang, Yong-Guang Zhang, Xiaoling Front Cell Dev Biol Cell and Developmental Biology Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently promote tumor cell proliferation, survival, metastasis and immune escape. Therefore, BET family proteins are considered attractive therapeutic targets in various cancers. Currently, blocking of the BET proteins is a widely used therapeutic strategy for MYCN amplified high-risk neuroblastoma. Here, we summarized and reviewed the recent research progresses for the critical function of BET proteins, as an epigenetic reader, on tumorigenesis and the therapeutic potential of the BET/BRD4 inhibitors on MYCN amplified neuroblastoma. We also discussed the combined therapeutic strategies for BET inhibitor-resistant neuroblastoma. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523081/ /pubmed/36187481 http://dx.doi.org/10.3389/fcell.2022.1021820 Text en Copyright © 2022 Shi, Wang, Zhang, Zhao, Dai, Yang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Shi, Xiyao
Wang, Ying
Zhang, Longhui
Zhao, Wenjie
Dai, Xiangpeng
Yang, Yong-Guang
Zhang, Xiaoling
Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
title Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
title_full Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
title_fullStr Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
title_full_unstemmed Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
title_short Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN
title_sort targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating mycn
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523081/
https://www.ncbi.nlm.nih.gov/pubmed/36187481
http://dx.doi.org/10.3389/fcell.2022.1021820
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