Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma

In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified in a broad range of cancers, including glioma. Despite the important function of IDH1 in tumorigenesis and its very polymorphic nature, it is not yet clear how...

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Detalles Bibliográficos
Autores principales: Suleman, Muhammad, Umme-I-Hani, Syeda, Salman, Muhammad, Aljuaid, Mohammed, Khan, Abbas, Iqbal, Arshad, Hussain, Zahid, Ali, Syed Shujait, Ali, Liaqat, Sher, Hassan, Waheed, Yasir, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523485/
https://www.ncbi.nlm.nih.gov/pubmed/36188571
http://dx.doi.org/10.3389/fphar.2022.927570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523485/
https://www.ncbi.nlm.nih.gov/pubmed/36188571
http://dx.doi.org/10.3389/fphar.2022.927570

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