Cargando…

Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma

In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified in a broad range of cancers, including glioma. Despite the important function of IDH1 in tumorigenesis and its very polymorphic nature, it is not yet clear how...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suleman, Muhammad, Umme-I-Hani, Syeda, Salman, Muhammad, Aljuaid, Mohammed, Khan, Abbas, Iqbal, Arshad, Hussain, Zahid, Ali, Syed Shujait, Ali, Liaqat, Sher, Hassan, Waheed, Yasir, Wei, Dong-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523485/ https://www.ncbi.nlm.nih.gov/pubmed/36188571 http://dx.doi.org/10.3389/fphar.2022.927570

Ejemplares similares

Are Nonsynonymous Transversions Generally More Deleterious than Nonsynonymous Transitions?
por: Zou, Zhengting, et al.
Publicado: (2020)

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene
por: Bappy, Md. Nazmul Islam, et al.
Publicado: (2022)

Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases
por: Wu, Jiaxin, et al.
Publicado: (2013)

Mutational analysis of the spike protein of SARS-COV-2 isolates revealed atomistic features responsible for higher binding and infectivity
por: Hanifa, Muhammad, et al.
Publicado: (2023)

In silico analysis for determining the deleterious nonsynonymous single nucleotide polymorphisms of BRCA genes
por: Yadegari, Fatemeh, et al.
Publicado: (2019)

Evaluation of the Whole Proteome of Achromobacter xylosoxidans to Identify Vaccine Targets for mRNA and Peptides-Based Vaccine Designing Against the Emerging Respiratory and Lung Cancer-Causing Bacteria
por: Khan, Taimoor, et al.
Publicado: (2022)

An In Silico Evaluation of Deleterious Nonsynonymous Single Nucleotide Polymorphisms in the ErbB3 Oncogene
por: Raghav, Dhwani, et al.
Publicado: (2013)

A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein
por: Akter, Mahmuda, et al.
Publicado: (2022)

Bioinformatics analysis of the differences in the binding profile of the wild-type and mutants of the SARS-CoV-2 spike protein variants with the ACE2 receptor
por: Suleman, Muhammad, et al.
Publicado: (2021)

Evaluation of Six Methods for Estimating Synonymous and Nonsynonymous Substitution Rates
por: Zhang, Zhang, et al.
Publicado: (2006)

A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene
por: Girmay, Shishay, et al.
Publicado: (2022)

Exploring the medicinal potential of Dark Chemical Matters (DCM) to design promising inhibitors for PLpro of SARS-CoV-2 using molecular screening and simulation approaches
por: Khan, Abbas, et al.
Publicado: (2023)

The Omicron (B.1.1.529) variant of SARS-CoV-2 binds to the hACE2 receptor more strongly and escapes the antibody response: Insights from structural and simulation data
por: Khan, Abbas, et al.
Publicado: (2022)

Unbiased Estimate of Synonymous and Nonsynonymous Substitution Rates with Nonstationary Base Composition
por: Guéguen, Laurent, et al.
Publicado: (2018)

Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene
por: Irfan, Muhammad, et al.
Publicado: (2022)

In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SARS-CoV-2: Structural-Dynamics and Free Energy Calculations
por: Khan, Abbas, et al.
Publicado: (2021)

Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction
por: Khan, Taimoor, et al.
Publicado: (2022)

Sequence and structure based assessment of nonsynonymous SNPs in hypertrichosis universalis
por: Waheed, Rabiya, et al.
Publicado: (2012)

Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study
por: Ait El Cadi, Chaimaa, et al.
Publicado: (2020)

Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity
por: Bouafi, Hind, et al.
Publicado: (2019)

Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis
por: Shinwari, Khyber, et al.
Publicado: (2021)

Prediction and expression analysis of deleterious nonsynonymous SNPs of Arabidopsis ACD11 gene by combining computational algorithms and molecular docking approach
por: Rifat, Mahmudul Hasan, et al.
Publicado: (2022)

Structural vaccinology-based design of multi-epitopes vaccine against Streptococcus gordonii and validation using molecular modeling and immune simulation approaches
por: Nasir, Syed Nouman, et al.
Publicado: (2023)

The Role of Deleterious Substitutions in Crop Genomes
por: Kono, Thomas J. Y., et al.
Publicado: (2016)

Nonlinear Dynamics of Nonsynonymous (d(N)) and Synonymous (d(S)) Substitution Rates Affects Inference of Selection
por: Wolf, Jochen B. W., et al.
Publicado: (2009)

An efficient and secure technique for image steganography using a hash function
por: Nezami, Zahid Iqbal, et al.
Publicado: (2022)

Effect of temperature and humidity on coronavirus infection in Pakistan
por: Akbar, Fazal, et al.
Publicado: (2022)

Genome bioinformatic analysis of nonsynonymous SNPs
por: Burke, David F, et al.
Publicado: (2007)

When a Synonymous Variant Is Nonsynonymous
por: Vihinen, Mauno
Publicado: (2022)

Towards an Ensemble Vaccine against the Pegivirus Using Computational Modelling Approaches and Its Validation through In Silico Cloning and Immune Simulation
por: Zheng, Bowen, et al.
Publicado: (2021)

Immunogenomics guided design of immunomodulatory multi-epitope subunit vaccine against the SARS-CoV-2 new variants, and its validation through in silico cloning and immune simulation
por: Khan, Abbas, et al.
Publicado: (2021)

Nonsynonymous Substitution Rate Heterogeneity in the Peptide-Binding Region Among Different HLA-DRB1 Lineages in Humans
por: Yasukochi, Yoshiki, et al.
Publicado: (2014)

Evidence-based tailoring of bioinformatics approaches to optimize methods that predict the effects of nonsynonymous amino acid substitutions in glucokinase
por: Šimčíková, Daniela, et al.
Publicado: (2017)

Synonymous and Nonsynonymous Substitutions in Dictyostelium discoideum Ammonium Transporter amtA Are Necessary for Functional Complementation in Saccharomyces cerevisiae
por: Densi, Asha, et al.
Publicado: (2023)

Structural and Biophysical Investigation of the Key Hotspots on the Surface of Epstein–Barr Nuclear Antigen 1 Essential for DNA Recognition and Pathogenesis
por: Hashmi, Huma Farooque, et al.
Publicado: (2021)

Pakistan as a major obstacle in global end to poliomyelitis program: background and 2016 update
por: Khan, Abdul Waheed, et al.
Publicado: (2016)

Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations
por: Parveen, Asia, et al.
Publicado: (2019)

Structural insights into the effect of mutations in the spike protein of SARS-CoV-2 on the binding with human furin protein
por: Suleman, Muhammad, et al.
Publicado: (2023)

A Novel Construction of Efficient Substitution-Boxes Using Cubic Fractional Transformation
por: Zahid, Amjad Hussain, et al.
Publicado: (2019)

Sorted gene genealogies and species-specific nonsynonymous substitutions point to putative postmating prezygotic isolation genes in Allonemobius crickets
por: Noh, Suegene, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ou5e59cdkqdh7ljq8kr6kjeqpg