Structural modeling of the hERG potassium channel and associated drug interactions

The voltage-gated potassium channel, K(V)11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential. Gating of the hERG channel is characterized by rapid, voltage-dependent, C-type inacti...

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Detalles Bibliográficos
Autores principales: Maly, Jan, Emigh, Aiyana M., DeMarco, Kevin R., Furutani, Kazuharu, Sack, Jon T., Clancy, Colleen E., Vorobyov, Igor, Yarov-Yarovoy, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523588/
https://www.ncbi.nlm.nih.gov/pubmed/36188564
http://dx.doi.org/10.3389/fphar.2022.966463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523588/
https://www.ncbi.nlm.nih.gov/pubmed/36188564
http://dx.doi.org/10.3389/fphar.2022.966463

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