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Development and in vivo validation of small interfering RNAs targeting NOX3 to prevent sensorineural hearing loss

The reactive oxygen species (ROS)-generating enzyme NOX3 has recently been implicated in the pathophysiology of several acquired forms of sensorineural hearing loss, including cisplatin-, noise- and age-related hearing loss. NOX3 is highly and specifically expressed in the inner ear and therefore re...

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Detalles Bibliográficos
Autores principales: Nacher-Soler, German, Marteyn, Antoine, Barenzung, Natasha, Sgroi, Stéphanie, Krause, Karl-Heinz, Senn, Pascal, Rousset, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523672/
https://www.ncbi.nlm.nih.gov/pubmed/36188374
http://dx.doi.org/10.3389/fneur.2022.993017