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Nanoscale Tracking Combined with Cell-Scale Microrheology Reveals Stepwise Increases in Force Generated by Cancer Cell Protrusions

[Image: see text] In early breast cancer progression, cancer cells invade through a nanoporous basement membrane (BM) as a first key step toward metastasis. This invasion is thought to be mediated by a combination of proteases, which biochemically degrade BM matrix, and physical forces, which mechan...

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Detalles Bibliográficos
Autores principales: Sikic, Luka, Schulman, Ester, Kosklin, Anna, Saraswathibhatla, Aashrith, Chaudhuri, Ovijit, Pokki, Juho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523704/
https://www.ncbi.nlm.nih.gov/pubmed/35950832
http://dx.doi.org/10.1021/acs.nanolett.2c01327