BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

Therapeutic options for treatment of basal-like breast cancers remain limited. Here, we demonstrate that bromodomain and extra-terminal (BET) inhibition induces an adaptive response leading to MCL1 protein-driven evasion of apoptosis in breast cancer cells. Consequently, co-targeting MCL1 and BET is...

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Detalles Bibliográficos
Autores principales: Yan, Gonghong, Luna, Augustin, Wang, Heping, Bozorgui, Behnaz, Li, Xubin, Sanchez, Maga, Dereli, Zeynep, Kahraman, Nermin, Kara, Goknur, Chen, Xiaohua, Zheng, Caishang, McGrail, Daniel, Sahni, Nidhi, Lu, Yiling, Babur, Ozgun, Cokol, Murat, Lim, Bora, Ozpolat, Bulent, Sander, Chris, Mills, Gordon B., Korkut, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523722/
https://www.ncbi.nlm.nih.gov/pubmed/36103824
http://dx.doi.org/10.1016/j.celrep.2022.111304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523722/
https://www.ncbi.nlm.nih.gov/pubmed/36103824
http://dx.doi.org/10.1016/j.celrep.2022.111304

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