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Rethinking intercurrent events in defining estimands for tuberculosis trials

BACKGROUND/AIMS: Tuberculosis remains one of the leading causes of death from an infectious disease globally. Both choices of outcome definitions and approaches to handling events happening post-randomisation can change the treatment effect being estimated, but these are often inconsistently describ...

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Detalles Bibliográficos
Autores principales: Pham, Tra My, Tweed, Conor D, Carpenter, James R, Kahan, Brennan C, Nunn, Andrew J, Crook, Angela M, Esmail, Hanif, Goodall, Ruth, Phillips, Patrick PJ, White, Ian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523802/
https://www.ncbi.nlm.nih.gov/pubmed/35850542
http://dx.doi.org/10.1177/17407745221103853