Inhibition of XPO1 with KPT-330 induces autophagy-dependent apoptosis in gallbladder cancer by activating the p53/mTOR pathway

BACKGROUND: Gallbladder cancer (GBC) is a highly aggressive malignant cancer in the biliary system with poor prognosis. XPO1 (chromosome region maintenance 1 or CRM1) mediates the nuclear export of several proteins, mainly tumor suppressors. Thus, XPO1 functions as a pro-oncogenic factor. KPT-330 (S...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Cheng, Yang, Zi-yi, Zhang, Jian, Li, Ou, Liu, Shi-lei, Cai, Chen, Shu, Yi-jun, Pan, Li-jia, Gong, Wei, Dong, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524043/
https://www.ncbi.nlm.nih.gov/pubmed/36180918
http://dx.doi.org/10.1186/s12967-022-03635-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524043/
https://www.ncbi.nlm.nih.gov/pubmed/36180918
http://dx.doi.org/10.1186/s12967-022-03635-w

Ejemplares similares