Cargando…

miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

BACKGROUND: Acute spinal cord injury (SCI) is a devastating result of neurological trauma with subsequent microenvironment dyshomeostasis that induces neurotoxic phenotype acquisition by astrocytes, exacerbating neurological function impairment. Exosomes derived from human umbilical cord mesenchymal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Xunwei, Wang, Yang, wang, Xiaokang, Liu, Bin, Rong, Limin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524140/ https://www.ncbi.nlm.nih.gov/pubmed/36175984 http://dx.doi.org/10.1186/s13287-022-03116-3

Ejemplares similares

High Induction of IL-6 Secretion From hUCMSCs Optimize the Potential of hUCMSCs and TCZ as Therapy for COVID-19-Related ARDS
por: Lo, Huei-Yu, et al.
Publicado: (2021)

Pyroptosis of MCF7 Cells Induced by the Secreted Factors of hUCMSCs
por: Jiao, Yang, et al.
Publicado: (2018)

hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke
por: Feng, Yi-wei, et al.
Publicado: (2020)

Human umbilical cord mesenchymal stromal cells promote the regeneration of severe endometrial damage in a rat model: hUCMSCs promote the recovery of severe endometrial damage
por: Zhuang, Mei, et al.
Publicado: (2021)

The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
por: Jiao, Yang, et al.
Publicado: (2020)

hUCMSCs carrying exenatide prevent T1DM by improving intestinal microflora composition and islet tissue damage repair
por: Wang, Wei, et al.
Publicado: (2022)

CGF Membrane Promotes Periodontal Tissue Regeneration Mediated by hUCMSCs through Upregulating TAZ and Osteogenic Differentiation Genes
por: Li, Wenjing, et al.
Publicado: (2021)

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice
por: Dong, Liyang, et al.
Publicado: (2021)

hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
por: Dong, Liyang, et al.
Publicado: (2020)

Engineering of pre-vascularized urethral patch with muscle flaps and hypoxia-activated hUCMSCs improves its therapeutic outcome
por: Sun, Dongchong, et al.
Publicado: (2014)

Transfer of lncRNA UCA1 by hUCMSCs-derived exosomes protects against hypoxia/reoxygenation injury through impairing miR-143-targeted degradation of Bcl-2
por: Diao, Liwei, et al.
Publicado: (2021)

A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles
por: Xu, Xiaowei, et al.
Publicado: (2023)

Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats
por: Wang, Yang, et al.
Publicado: (2021)

Anti-tumor Effects of IL-1β Induced TRAIL-Expressing hUCMSCs on Embelin Treated Breast Cancer Cell Lines
por: Teng, Jui-Wen, et al.
Publicado: (2023)

A simple and efficient strategy for cell‐based and cell‐free‐based therapies in acute liver failure: hUCMSCs bioartificial liver
por: Feng, Lei, et al.
Publicado: (2023)

A novel method to improve the osteogenesis capacity of hUCMSCs with dual‐directional pre‐induction under screened co‐culture conditions
por: Rong, Qiong, et al.
Publicado: (2019)

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSC-mediated alleviation of decompensated liver cirrhosis in rats
por: Yao, Yunqi, et al.
Publicado: (2023)

Effectiveness of Secretome from Human Umbilical Cord Mesenchymal Stem Cells in Gel (10% SM-hUCMSC Gel) for Chronic Wounds (Diabetic and Trophic Ulcer) – Phase 2 Clinical Trial
por: Tan, Sukmawati Tansil, et al.
Publicado: (2023)

IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation via the Foxp3/ROR-γt/STAT3 Signaling Pathway in an Animal Model of Multiple Sclerosis
por: Ling, Xiao, et al.
Publicado: (2022)

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn(+) colorectal cancer cells from modifying their O-glycosylation status
por: Hu, Wen, et al.
Publicado: (2023)

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes
por: Jiang, Dongdong, et al.
Publicado: (2020)

Comparison of effects of HucMSCs, exosomes, and conditioned medium on NASH
por: Liang, Chenchen, et al.
Publicado: (2023)

IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial–mesenchymal transition in epithelial ovarian cancer
por: Zhang, Yunxia, et al.
Publicado: (2018)

A Response to Article “Effectiveness of Secretome from Human Umbilical Cord Mesenchymal Stem Cells in Gel (10% SM-hUCMSC Gel) for Chronic Wounds (Diabetic and Trophic Ulcer) – Phase 2 Clinical Trial” [Letter]
por: Dwicantika, Annisa, et al.
Publicado: (2023)

hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms
por: Luo, Qianqian, et al.
Publicado: (2022)

Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy
por: Wang, Bingying, et al.
Publicado: (2017)

HucMSC‐exosomes carrying miR‐326 inhibit neddylation to relieve inflammatory bowel disease in mice
por: Wang, Gaoying, et al.
Publicado: (2020)

SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis
por: Wang, Yun-Liang, et al.
Publicado: (2018)

Human umbilical cord mesenchymal stem cell derived exosomes (HUCMSC-exos) recovery soluble fms-like tyrosine kinase-1 (sFlt-1)-induced endothelial dysfunction in preeclampsia
por: Chang, Xinwen, et al.
Publicado: (2023)

A New Self-Healing Hydrogel Containing hucMSC-Derived Exosomes Promotes Bone Regeneration
por: Wang, Li, et al.
Publicado: (2020)

Inhibition of astrocyte hemichannel improves recovery from spinal cord injury
por: Zhang, Chao, et al.
Publicado: (2021)

hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice
por: Xiao, Yue, et al.
Publicado: (2023)

HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes
por: Zhang, Ying-Yi, et al.
Publicado: (2023)

MiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury
por: Pei, Zhipeng, et al.
Publicado: (2023)

Astrocyte transplantation for repairing the injured spinal cord
por: Zheng, Xiaolong, et al.
Publicado: (2022)

Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity
por: Deng, Zhiting, et al.
Publicado: (2021)

Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats
por: Wang, Xiujuan, et al.
Publicado: (2023)

Transplantation of Specific Human Astrocytes Promotes Functional Recovery after Spinal Cord Injury
por: Davies, Stephen J. A., et al.
Publicado: (2011)

HUCMSC‐derived Exosomes Suppress the Titanium Particles‐induced Osteolysis in Mice through Inhibiting CCL2 and CCL3
por: Li, Shixun, et al.
Publicado: (2023)

Exosomes derived from human umbilical cord mesenchymal stem cells reduce tendon injuries via the miR-27b-3p/ARHGAP5/RhoA signaling pathway: Influences of hucMSC-exosomes in tendon injuries
por: Han, Qinghui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_he73if2u511288g2nq76uh7pt6