DSTYK inhibition increases the sensitivity of lung cancer cells to T cell–mediated cytotoxicity

Lung cancer remains the leading cause of cancer-related death worldwide. We identify DSTYK, a dual serine/threonine and tyrosine non-receptor protein kinase, as a novel actionable target altered in non-small cell lung cancer (NSCLC). We also show DSTYK's association with a lower overall surviva...

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Detalles Bibliográficos
Autores principales: Valencia, Karmele, Echepare, Mirari, Teijeira, Álvaro, Pasquier, Andrea, Bértolo, Cristina, Sainz, Cristina, Tamayo, Ibon, Picabea, Beñat, Bosco, Graziella, Thomas, Roman, Agorreta, Jackeline, López-Picazo, José María, Frigola, Joan, Amat, Ramon, Calvo, Alfonso, Felip, Enriqueta, Melero, Ignacio, Montuenga, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524203/
https://www.ncbi.nlm.nih.gov/pubmed/36169652
http://dx.doi.org/10.1084/jem.20220726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524203/
https://www.ncbi.nlm.nih.gov/pubmed/36169652
http://dx.doi.org/10.1084/jem.20220726

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