Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway

Intervertebral disc (IVD) degeneration (IVDD) which is highly prevalent within the elderly population, is a leading cause of chronic low back pain and disability. Nucleus pulposus (NP) cell senescence plays an indispensable role in the pathogenesis of IVDD. Morroniside is a major iridoid glycoside a...

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Detalles Bibliográficos
Autores principales: Zhou, Chengcong, Yao, Sai, Fu, Fangda, Bian, Yishan, Zhang, Zhiguo, Zhang, Huihao, Luo, Huan, Ge, Yuying, Chen, Yuying, Ji, Weifeng, Tian, Kun, Yue, Ming, Jin, Hongting, Tong, Peijian, Wu, Chengliang, Ruan, Hongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524229/
https://www.ncbi.nlm.nih.gov/pubmed/36188539
http://dx.doi.org/10.3389/fphar.2022.942435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524229/
https://www.ncbi.nlm.nih.gov/pubmed/36188539
http://dx.doi.org/10.3389/fphar.2022.942435

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