Cargando…
Nanoparticle-mediated Delivery of IL-2 To T Follicular Helper Cells Protects BDF1 Mice from Lupus-like Disease
We recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells (Tregs). Here we show that the protection from disease and t...
Autores principales: | Ferretti, Concetta, Horwitz, David A., Bickerton, Sean, La Cava, Antonio |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524795/ https://www.ncbi.nlm.nih.gov/pubmed/36465067 http://dx.doi.org/10.2478/rir-2021-0024 |
Ejemplares similares
-
Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
por: Horwitz, David A., et al.
Publicado: (2020) -
Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases
por: Horwitz, David A., et al.
Publicado: (2021) -
Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4(+) and CD8(+) Tregs That Are Functional in Humanized Mice
por: Giang, Sophia, et al.
Publicado: (2021) -
Follicular Helper T Cells in Systemic Lupus Erythematosus
por: Kim, Sun Jung, et al.
Publicado: (2018) -
BDF target prototype assembly
por: Ordan, Julien Marius
Publicado: (2018)