Contribution of Impaired DNASE1L3 Activity to Anti-DNA Autoantibody Production in Systemic Lupus Erythematosus

Anti-DNA autoantibodies are pathogenic in systemic lupus erythematosus (SLE). Cell-free chromatin associated long DNA fragments are antigens for anti-DNA antibodies. In health state, released by cell death and actively secreted by live cells, these cell-free DNA are cleared by deoxyribonucleases (DN...

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Detalles Bibliográficos
Autores principales: Mathapathi, Samarth, Chu, Cong-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524810/
https://www.ncbi.nlm.nih.gov/pubmed/36467024
http://dx.doi.org/10.2478/rir-2022-0003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524810/
https://www.ncbi.nlm.nih.gov/pubmed/36467024
http://dx.doi.org/10.2478/rir-2022-0003

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