Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway

The fate of pyruvate is a defining feature in many cell types. One major fate is mitochondrial entry via the mitochondrial pyruvate carrier (MPC). We found that diffuse large B cell lymphomas (DLBCLs) consume mitochondrial pyruvate via glutamate-pyruvate transaminase 2 to enable α-ketoglutarate prod...

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Detalles Bibliográficos
Autores principales: Wei, Peng, Bott, Alex J., Cluntun, Ahmad A., Morgan, Jeffrey T., Cunningham, Corey N., Schell, John C., Ouyang, Yeyun, Ficarro, Scott B., Marto, Jarrod A., Danial, Nika N., DeBerardinis, Ralph J., Rutter, Jared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524954/
https://www.ncbi.nlm.nih.gov/pubmed/36179030
http://dx.doi.org/10.1126/sciadv.abq0117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524954/
https://www.ncbi.nlm.nih.gov/pubmed/36179030
http://dx.doi.org/10.1126/sciadv.abq0117

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