Potency of the novel PolC DNA polymerase inhibitor CRS0540 in a disseminated Listeria monocytogenes intracellular hollow-fibre model

BACKGROUND: Listeriosis is an orphan disease, which is nevertheless fatal in immunocompromised people. CRS0540 is a novel PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes. METHODS: Rodent-to-human allometry projection-based human p...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Swati, Chapagain, Moti, Mason, Clifford, Gingrich, Matthew, Athale, Shruti, Ribble, Wendy, Hoang, Teresa, Day, Joshua, Sun, Xicheng, Jarvis, Thale, Ochsner, Urs A, Howe, David, Gumbo, Tawanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525089/
https://www.ncbi.nlm.nih.gov/pubmed/35929190
http://dx.doi.org/10.1093/jac/dkac269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525089/
https://www.ncbi.nlm.nih.gov/pubmed/35929190
http://dx.doi.org/10.1093/jac/dkac269

Ejemplares similares