HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity

Adoptive cell therapy (ACT) with tumor-specific memory T cells has shown increasing efficacy in regressing solid tumors. However, tumor antigen heterogeneity represents a longitudinal challenge for durable clinical responses due to the therapeutic selective pressure for immune escape variants. Here,...

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Detalles Bibliográficos
Autores principales: Nguyen, Andrew, Ho, Louisa, Hogg, Richard, Chen, Lan, Walsh, Scott R., Wan, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525113/
https://www.ncbi.nlm.nih.gov/pubmed/35972798
http://dx.doi.org/10.1172/JCI159283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525113/
https://www.ncbi.nlm.nih.gov/pubmed/35972798
http://dx.doi.org/10.1172/JCI159283

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