Cargando…

TDO2(+) myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma

Characterization of the dynamic change in the immunological landscape during malignant transformation from precancerous lesions to cancerous lesions in squamous cell carcinoma (SCC) is critical for the application of immunotherapy. Here, we performed single-cell RNA-Seq (scRNA-Seq) of 131,702 cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Simeng, Lu, Huanzi, Xie, Wenqiang, Wang, Dikan, Shan, Zhongyan, Xing, Xudong, Wang, Xiang-Ming, Fang, Juan, Dong, Wei, Dai, Wenxiao, Guo, Junyi, Zhang, Yanshu, Wen, Shuqiong, Guo, Xin-Yu, Chen, Qianming, Bai, Fan, Wang, Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525123/ https://www.ncbi.nlm.nih.gov/pubmed/35972800 http://dx.doi.org/10.1172/JCI157649

Ejemplares similares

A comprehensive profile of TCF1(+) progenitor and TCF1(−) terminally exhausted PD-1(+)CD8(+) T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy
por: Wang, Dikan, et al.
Publicado: (2022)

High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis
por: Lu, Huanzi, et al.
Publicado: (2020)

Dynamic changes of exhaustion features in T cells during oral carcinogenesis
por: Xie, Wenqiang, et al.
Publicado: (2022)

Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications
por: Xie, Wenqiang, et al.
Publicado: (2022)

Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma
por: Li, Qunxing, et al.
Publicado: (2020)

TDO Promotes Hepatocellular Carcinoma Progression
por: Li, Shanbao, et al.
Publicado: (2020)

Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis
por: Wen, Liling, et al.
Publicado: (2019)

Correction to: Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis
por: Wen, Liling, et al.
Publicado: (2022)

Time Difference of Arrival (TDoA) Localization Combining Weighted Least Squares and Firefly Algorithm
por: Wu, Peng, et al.
Publicado: (2019)

TDO2 Promotes the EMT of Hepatocellular Carcinoma Through Kyn-AhR Pathway
por: Li, Lei, et al.
Publicado: (2021)

Comprehensive Analysis of the Expressionand Prognosis for TDO2 in Breast Cancer
por: Liu, Qiang, et al.
Publicado: (2020)

The niche-specialist and age-related oral microbial ecosystem: crosstalk with host immune cells in homeostasis
por: Lin, Dongjia, et al.
Publicado: (2022)

A clinical signature predicting the malignant transformation of inflammatory myofibroblastic tumor in the head and neck
por: Peng, Cangbang, et al.
Publicado: (2022)

On the Non-Redundant Roles of TDO2 and IDO1
por: Puccetti, Paolo
Publicado: (2014)

Pharmacological validation of TDO as a target for Parkinson’s disease
por: Perez‐Pardo, Paula, et al.
Publicado: (2021)

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors
por: Platten, Michael, et al.
Publicado: (2015)

Identification and optimisation of next generation inhibitors of IDO1 and TDO
por: Wise, Alan, et al.
Publicado: (2015)

Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications
por: Ye, Zixiang, et al.
Publicado: (2019)

Clinicopathologic features of TDO2 overexpression in renal cell carcinoma
por: Pham, Quoc Thang, et al.
Publicado: (2021)

Wideband TDoA Positioning Exploiting RSS-Based Clustering
por: Fuchs, Andreas, et al.
Publicado: (2023)

IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era
por: Chen, Xiangli, et al.
Publicado: (2020)

Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway
por: Du, Lisha, et al.
Publicado: (2020)

Involvement of potential pathways in malignant transformation from Oral Leukoplakia to Oral Squamous Cell Carcinoma revealed by proteomic analysis
por: Wang, Zhi, et al.
Publicado: (2009)

Pancancer Analysis of Revealed TDO2 as a Biomarker of Prognosis and Immunotherapy
por: Cui, Jing, et al.
Publicado: (2022)

Malignant transformation of inflammatory myofibroblastic tumor of urinary bladder: A rare case scenario
por: Inamdar, Arati A., et al.
Publicado: (2019)

Correction: Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway
por: Du, Lisha, et al.
Publicado: (2021)

Putative biomarkers of malignant transformation of sinonasal inverted papilloma into squamous cell carcinoma
por: Yang, Zheng, et al.
Publicado: (2019)

Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target
por: Wang, Ru, et al.
Publicado: (2023)

Analysis and Accuracy Improvement of UWB-TDoA-Based Indoor Positioning System
por: Grasso, Paolo, et al.
Publicado: (2022)

Kidney inflammatory myofibroblastic tumor masquerading as metastatic malignancy: A case report and literature review
por: Zhang, Guo-Hui, et al.
Publicado: (2019)

Preclinical PK investigation of a novel IDO1/TDO dual inhibitor—SHR9146 in mouse plasma and tissues by LC-MS/MS
por: Xiao, Mei, et al.
Publicado: (2023)

Organ Correlation with Tryptophan Metabolism Obtained by Analyses of TDO-KO and QPRT-KO Mice
por: Shibata, Katsumi, et al.
Publicado: (2016)

Two New Shrinking-Circle Methods for Source Localization Based on TDoA Measurements
por: Luo, Mingzhi, et al.
Publicado: (2018)

Comprehensive behavioral analysis of tryptophan 2,3‐dioxygenase (Tdo2) knockout mice
por: Hattori, Satoko, et al.
Publicado: (2018)

Utilization of Carrier-Frequency Offset Measurements in UWB TDoA Positioning with Receiving Tag
por: Krška, Josef, et al.
Publicado: (2023)

Myofibroblasts and their relationship with oral squamous cell carcinoma
por: Lúcio, Priscilla Suassuna Carneiro, et al.
Publicado: (2015)

MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma
por: Ai, Yang, et al.
Publicado: (2022)

Stromal myofibroblasts in potentially malignant and malignant lesions of the oral cavity
por: RODRIGUES, PRISCILA CAMPIONI, et al.
Publicado: (2015)

Investigation of the Performance of TDoA-Based Localization Over LoRaWAN in Theory and Practice
por: Pospisil, Jan, et al.
Publicado: (2020)

Particle Filtering for Three-Dimensional TDoA-Based Positioning Using Four Anchor Nodes
por: Khalaf-Allah, Mohamed
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1sq1n31ranho1fo1qu4jtu7tv1