Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

Overexpression of MYC is a genuine cancer driver in lymphomas and related to poor prognosis. However, therapeutic targeting of the transcription factor MYC remains challenging. Here, we show that inhibition of the histone deacetylase 6 (HDAC6) using the HDAC6 inhibitor Marbostat-100 (M-100) reduces...

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Detalles Bibliográficos
Autores principales: Winkler, René, Mägdefrau, Ann-Sophie, Piskor, Eva-Maria, Kleemann, Markus, Beyer, Mandy, Linke, Kevin, Hansen, Lisa, Schaffer, Anna-Maria, Hoffmann, Marina E., Poepsel, Simon, Heyd, Florian, Beli, Petra, Möröy, Tarik, Mahboobi, Siavosh, Krämer, Oliver H., Kosan, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525236/
https://www.ncbi.nlm.nih.gov/pubmed/36068335
http://dx.doi.org/10.1038/s41388-022-02450-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525236/
https://www.ncbi.nlm.nih.gov/pubmed/36068335
http://dx.doi.org/10.1038/s41388-022-02450-3

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