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Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how intracellular glutathione can be elevated transiently to...

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Detalles Bibliográficos
Autores principales: Wijaya, Lukas S., Rau, Carina, Braun, Theresa S., Marangoz, Serif, Spegg, Vincent, Vlasveld, Matthijs, Albrecht, Wiebke, Brecklinghaus, Tim, Kamp, Hennicke, Beltman, Joost B., Hengstler, Jan G., van de Water, Bob, Leist, Marcel, Schildknecht, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525367/
https://www.ncbi.nlm.nih.gov/pubmed/34021431
http://dx.doi.org/10.1007/s10565-021-09610-3