Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics

Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recurrence. We investigated the therapeutic potential of targeting anti-apoptotic BCL-2 proteins...

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Detalles Bibliográficos
Autores principales: Koessinger, Anna L., Cloix, Catherine, Koessinger, Dominik, Heiland, Dieter Henrik, Bock, Florian J., Strathdee, Karen, Kinch, Kevin, Martínez-Escardó, Laura, Paul, Nikki R., Nixon, Colin, Malviya, Gaurav, Jackson, Mark R., Campbell, Kirsteen J., Stevenson, Katrina, Davis, Sandeep, Elmasry, Yassmin, Ahmed, Asma, O’Prey, Jim, Ichim, Gabriel, Schnell, Oliver, Stewart, William, Blyth, Karen, Ryan, Kevin M., Chalmers, Anthony J., Norman, Jim C., Tait, Stephen W. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525582/
https://www.ncbi.nlm.nih.gov/pubmed/35473984
http://dx.doi.org/10.1038/s41418-022-01001-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525582/
https://www.ncbi.nlm.nih.gov/pubmed/35473984
http://dx.doi.org/10.1038/s41418-022-01001-3

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