CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model

CD80 interact with CD28 and CTLA-4 on antigen-presenting cells, and function in the co-stimulatory signaling that regulates T cell activity. CTLA-4-Ig is used to treat RA by blocking co-stimulatory signaling. Chronic inflammatory arthritis was induced in D1BC mice using low-dose arthritogenic antige...

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Detalles Bibliográficos
Autores principales: Miura, Yoko, Isogai, Shyuntaro, Maeda, Shinji, Kanazawa, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525600/
https://www.ncbi.nlm.nih.gov/pubmed/36180526
http://dx.doi.org/10.1038/s41598-022-20694-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525600/
https://www.ncbi.nlm.nih.gov/pubmed/36180526
http://dx.doi.org/10.1038/s41598-022-20694-7

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