O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and its dismal prognosis indicates the urgent need to elucidate the potential oncogenic mechanisms. SIRT7 is a classic NAD(+)-dependent deacetylase that stabilizes the transformed state of cancer cells. However, its functional...

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Detalles Bibliográficos
Autores principales: He, Xiaoman, Li, Yongzhou, Chen, Qing, Zheng, Lei, Lou, Jianyao, Lin, Chuanshuai, Gong, Jiali, Zhu, Yi, Wu, Yulian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525610/
https://www.ncbi.nlm.nih.gov/pubmed/35422493
http://dx.doi.org/10.1038/s41418-022-00984-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525610/
https://www.ncbi.nlm.nih.gov/pubmed/35422493
http://dx.doi.org/10.1038/s41418-022-00984-3

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