Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani

We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8–C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 lin...

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Detalles Bibliográficos
Autores principales: Prasad, Surendra Rajit, Kumar, Prakash, Mandal, Saptarshi, Mohan, Anu, Chaurasia, Radhika, Shrivastava, Ashish, Nikhil, Pallaprolu, Aishwarya, Dande, Ramalingam, P., Gajbhiye, Rahul, Singh, Shriya, Dasgupta, Arunava, Chourasia, Mukesh, Ravichandiran, V., Das, Prolay, Mandal, Debabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525708/
https://www.ncbi.nlm.nih.gov/pubmed/36180490
http://dx.doi.org/10.1038/s41598-022-20509-9

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