Heterogeneity in viral populations increases the rate of deleterious mutation accumulation

RNA viruses have high mutation rates, with the majority of mutations being deleterious. We examine patterns of deleterious mutation accumulation over multiple rounds of viral replication, with a focus on how cellular coinfection and heterogeneity in viral output affect these patterns. Specifically,...

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Detalles Bibliográficos
Autores principales: Allman, Brent, Koelle, Katia, Weissman, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526070/
https://www.ncbi.nlm.nih.gov/pubmed/35993909
http://dx.doi.org/10.1093/genetics/iyac127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526070/
https://www.ncbi.nlm.nih.gov/pubmed/35993909
http://dx.doi.org/10.1093/genetics/iyac127

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