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Heterogeneity in viral populations increases the rate of deleterious mutation accumulation
RNA viruses have high mutation rates, with the majority of mutations being deleterious. We examine patterns of deleterious mutation accumulation over multiple rounds of viral replication, with a focus on how cellular coinfection and heterogeneity in viral output affect these patterns. Specifically,...
Autores principales: | Allman, Brent, Koelle, Katia, Weissman, Daniel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526070/ https://www.ncbi.nlm.nih.gov/pubmed/35993909 http://dx.doi.org/10.1093/genetics/iyac127 |
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