Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules

Insulin is synthesized by pancreatic β-cells and stored into secretory granules (SGs). SGs fuse with the plasma membrane in response to a stimulus and deliver insulin to the bloodstream. The mechanism of how proinsulin and its processing enzymes are sorted and targeted from the trans-Golgi network (...

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Detalles Bibliográficos
Autores principales: Parchure, Anup, Tian, Meng, Stalder, Danièle, Boyer, Cierra K., Bearrows, Shelby C., Rohli, Kristen E., Zhang, Jianchao, Rivera-Molina, Felix, Ramazanov, Bulat R., Mahata, Sushil K., Wang, Yanzhuang, Stephens, Samuel B., Gershlick, David C., von Blume, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526250/
https://www.ncbi.nlm.nih.gov/pubmed/36173346
http://dx.doi.org/10.1083/jcb.202206132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526250/
https://www.ncbi.nlm.nih.gov/pubmed/36173346
http://dx.doi.org/10.1083/jcb.202206132

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